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Ot detectable (ND) in SP-A-/- mice.lower than at 4 hr (40/19 = 2.1), although the increases continue to predominate. However, most of this change is due to the PMM group, which has reverted at the 24 hr point post-infection to having more than twice as many proteins (9 of 13) at reduced levels in the SP-A-/- mice, as was the case in control (baseline) SP-A-/- mice. The overall numbers of increase
Esults in an increased sensitivity to TGF-beta signaling. BMC Cancer. 2011;11:59. PubMed. 31. Imamichi Y, Waidmann O, Hein R, Eleftheriou P, Giehl K, Menke A. TGF betainduced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol Chem. 2005;386(3):225-236. PubMed. 32. Gauger KJ, Shimono A, Crisi GM, Schneider SS. Loss of SFRP
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I:10.1371/journal.pone.0127641. PubMed PMID: 26011708; PMCID: PMC4444265. 40. Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H. Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci. 2013;14(8):16226-39. doi:10.3390/ijms140816226. PubMed PMID: 23924943; PMCID: PMC3759908. 41. Yin P, Navarro A, Fang F, Xie A, Coon JS, Richardson C,
I:10.1371/journal.pone.0127641. PubMed PMID: 26011708; PMCID: PMC4444265. 40. Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H. Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci. 2013;14(8):16226-39. doi:10.3390/ijms140816226. PubMed PMID: 23924943; PMCID: PMC3759908. 41. Yin P, Navarro A, Fang F, Xie A, Coon JS, Richardson C,
(?- or -shaped response pattern) toward the levels seen under baseline conditions, suggesting a peak response at 4 hr(or at least earlier than 24 hr). 3) In a third set (n = 5), levels of some proteins at 24 hr were continuing to either increase or decrease from levels seen at 4 hr, suggesting slower and/or more sustained responses to infection. With respect to all identified proteins, the ratio
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Between 4 hours and 24 hours post infection (Continued)57 60 Serine (or cysteine) proteinase inhibitor, clade A, member 1e Tyrosine-3-monooxygenase/tryptophan 5-monooxynase activation protein, Epsilon polypeptide Q00898 Q8BPH1 -9.83 33.02 -3.86 4.Changes ( ) in BAL protein expression that were similar for wild-type (WT) and SP-A-/- mice between 4 and 24 hours post infection are shown. Gel number
I:10.1371/journal.pone.0127641. PubMed PMID: 26011708; PMCID: PMC4444265. 40. Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H. Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci. 2013;14(8):16226-39. doi:10.3390/ijms140816226. PubMed PMID: 23924943; PMCID: PMC3759908. 41. Yin P, Navarro A, Fang F, Xie A, Coon JS, Richardson C,
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